Anti-Rh(D) immunoglobulin is administered to non-immune Rh-negative women, i.e. women who do not have anti-Rh antibodies, as once anti-Rh antibodies appear, it won’t be effective:
• in the 28th week of pregnancy (antenatal prophylaxis of haemolytic disease).
• immediately after birth, if the child is Rh positive (postpartum prophylaxis)
• after an amniocentesis or any other diagnostic or therapeutic procedure involving puncture has been carried out
• after a spontaneous or therapeutic termination
• if the woman presents with blood loss, with a threat of miscarriage
• after an abdominal trauma (for example, a road traffic accident)
Anti-Rh(D) immunoglobulin is injected intramuscularly or intravenously, according to the preparation used, and remains effective for at least six weeks.